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Sadanandan E. Velu, PhD

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Dr. Velu is a tenured Professor in the Chemistry Department of University of Alabama at Birmingham. He holds co-appointments as a Scientist at the UAB O’Neal Comprehensive Cancer Center Experimental Therapeutics Program and as an Associate Scientist at the UAB Center for Clinical and Translational Sciences. His research, funded by NIH and AHA focuses on drug discovery and development. His research interests are in the areas of medicinal chemistry, anti-cancer and anti-infective agents, structure based drug design, in-silico screening, directed combinatorial synthesis, structure activity relationship studies, lead optimization and synthesis of marine natural products. He is the author/co-author of >65 peer reviewed research publications and the inventor/co-inventor of 6 issued US/European patents.  He serves on the NIH and AHA study sections. He teaches both graduate and undergraduate courses and is a recipient of the National Award for Excellence in Teaching given by the Center for Educational Policy Research, College Board. He currently serves as the Co-Director of the Undergraduate Program in Cancer Biology at UAB.

Professor
email
Chemistry Building 280
(205) 975-2478

Recent Articles

  1. Piyasuda Pukkanasut, Renata Jaskula-Sztul, Juan Carlos Gomora, and Sadanandan E. Velu, Therapeutic Targeting of Voltage-gated Sodium Channel NaV1.7 for Cancer Metastasis, Frontiers in Pharmacology (2024), IN PRESS.

  2. Osbaldo Lopez-Charcas, Oumnia Benouna, Roxane Lemoine, Zazil Herrera-Carrillo, Margarita Jacaranda Rosendo-Pineda, Miguel Ramírez-Aragon, Tonantzin Guadalupe Anguheven-Ledezma, Ana Alfaro, Stephanie Chadet, Fabio Ferro, Pierre Besson, Lin-Hua Jiang, Sadanandan E. Velu, Sebastien Roger and Juan Carlos Gomora, Gossypol’s Blocking Mechanism on CaV3 Calcium Channels and Induction of G0/G1 Cell Cycle Arrest in Colon Cancer Cells, British Journal of Pharmacology (2024), IN PRESS.

  3. Edwin M. Rojas, Hua Zhang, Sadanandan E. Velu, and Hui Wu, Tetracyclic homoisoflavanoid (+)-brazilin: A new inhibitor of c-di-AMP production by Streptococcus mutans, Microbiology Spectrum (2024), 12, e0241823, PubMed PMID: 38591917, PubMed PMCID: PMC11064632, DOI: 10.1128/spectrum.02418-23.

  4. Parmanand Ahirwar, Veronika Kozlovskaya, Bhavitavya Nijampatnam, Edwin M. Rojas, Piyasuda Pukkanasut, Daniel Inman, Maksim Dolmat, Anna C. Law, Norbert Schormann, Champion Deivanayagam, Gregory J. Harber, Suzanne M. Michalek, Hui Wu, Eugenia Kharlampieva and Sadanandan E. Velu, Hydrogel encapsulated biofilm inhibitors abrogate the cariogenic activity of Streptococcus mutans, Journal of Medicinal Chemistry (2023), 66, 7909-7925. DOI: 10.1021/acs.jmedchem.3c00272.

  5. Piyasuda Pukkanasut, Jason Whitt, Rachael Guenter, Shannon E Lynch, Carlos Gallegos, Margarita Jacaranda Rosendo-Pineda, Juan Carlos Gomora, Herbert Chen, Diana Lin, Anna Sorace, Renata Jaskula-Sztul and Sadanandan E. Velu, Voltage-gated Sodium Channel NaV1.7 Inhibitors with Potent Anticancer Activities in Medullary Thyroid Cancer Cells, Cancers (2023), 15(10), 2806, PubMed PMCID: PMC10216335, DOI: 10.3390/cancers15102806.

  6. Osbaldo Lopez-Charcas, Lucile Poisson, Oumnia Benouna, Roxane Lemoine, Stéphanie Chadet, Adrien Pétereau, Widad Lahlou, Serge Guyétant, Mehdi Ouaissi, Piyasuda Pukkanasut, Shilpa Dutta, Sadanandan E. Velu, Pierre Besson, Driffa Moussata, and Sébastien Roger, Voltage-Gated Sodium Channel NaV1.5 Controls NHE-1-Dependent Invasive Properties in Colon Cancer Cells, Cancers (2023), 15: 46, PubMed PMID: 36612049, PubMed PMCID: PMC9817685, DOI: 10.3390/cancers15010046.

  7. Cuijuan Han, Alireza Khodadadi-Jamayran, Adam H. Lorch, Qi Jin, Valentina Serafin, Ping Zhu, Yuliya Politanska, Limin Sun, Blanca T. Gutierrez-Diaz, Marina V. Pryzhkova, Hiam Abdala-Valencia, Elizabeth Thomas Bartom, Barbara Buldini, Giuseppe Basso, Sadanandan E. Velu, Kavitha Sarma, Basil B. Mattamana, Byoung-Kyu Cho, Rebecca C. Obeng, Young Ah Goo, Philip W. Jordan, Aristotelis Tsirigos, Yalu Zhou, Panagiotis Ntziachristos, SF3B1 homeostasis is critical for survival and therapeutic response in T cell leukemia, Science Advances (2022), 8, eabj8357, PubMed PMID: 35061527, PubMed PMCID: PMC8782448, DOI: 10.1126/sciadv.abj8357.

  8. Zekiye Ceren Arituluk, Jesse Horne, Bishnu Adhikari, Jeffrey Steltzner, Shomit Mansur, Parmanand Ahirwar, Sadanandan E. Velu, Nora E. Gray, Lukasz M. Ciesla and Yuping Bao,  Identification of TrkB Binders from Complex Matrices Using a Magnetic Drug Screening Nanoplatform, ACS Appl. Bio Mater. (2021), 4: 6244–6255, DOI: 10.1021/acsabm.1c00552.,  DOI: 10.1021/acsabm.1c00552.

  9. Chandni Desai, Jon Thomason, Jordan Kohlmeyer, Anna Reisetter, Parmanand Ahirwar, Khadijeh Jahanseir, Mariah Leidinger, Georgina Ofori-Amanfo, Karen Fritchie, Sadanandan E. Velu, Patrick Breheny, Dawn Quelle, and Munir Tanas, Prognostic and therapeutic value of the Hippo pathway, RABL6A, and p53-MDM2 axes in sarcomas, Submitted to Oncotarget,  12: 740-755 (2021), PubMed PMID: 33889298, PubMed PMCID: PMC8057271, DOI: 10.18632/oncotarget.27928.

  10. Bhavitavya Nijampatnam, Parmanand Ahirwar, Piyasuda Pukkanasut, Holly Womack, Luke Casals, Hua Zhang, Xia Cai, Suzanne M. Michalek, Hui Wu, and Sadanandan E. Velu, Discovery of Potent Inhibitors of Streptococcus mutans Biofilm with Antivirulence Activity, ACS Medicinal Chemistry Letters,  12 (1): 48–55 (2021), PubMed PMID: 33488963, PubMed PMCID: PMC7812604, DOI: 10.1021/acsmedchemlett.0c00373.

  11. Michiel van Gent, Adrian Reich, Sadanandan E. Velu, and Michaela U. Gack, Nonsense-mediated decay controls the reactivation of the oncogenic herpesviruses EBV and KSHV, Plos Biology, 19(2): e3001097 (2021), PubMed PMID: 33596193, DOI: 10.1371/journal.pbio.3001097.

  12. Osbaldo Lopez-Charcas, Piyasuda Pukkanasut, Sadanandan E. Velu, William J. Brackenbury, Tim G. Hales, Pierre Besson, Juan Carlos Gomora, Sebastien Roger, Pharmacological and nutritional targeting of voltage-gated sodium channels in the treatment of cancers, iScience, 24: 102270 (2021), PubMed PMID: 33817575, PubMed PMCID: PMC8010468, DOI: 10.1016/j.isci.2021.102270.

  13. Zviadi Aburjania, Jason D Whitt, Samuel Jang, Dwayaja H Nadkarni, Herbert Chen, J Bart Rose, Sadanandan E Velu (Co-corresponding author) and Renata Jaskula-Sztul, Synthetic Makaluvamine Analogs Decrease c-Kit Expression and Are Cytotoxic to Neuroendocrine Tumor Cells, Molecules, 25 (21): 4940 (2020), PubMed PMID: 33114525; PubMed PMCID: PMC7663375. DOI: 10.3390/molecules25214940.

  14. Jaden Cowan, Mohammad Shadab, Dwayaja H. Nadkarni, Kailash KC, Sadanandan E. Velu (Co-corresponding author) and Nabiha Yusuf, A Novel Marine Natural Product Derived Pyrroloiminoquinone with Potent Activity against Skin Cancer Cells, Marine Drugs, 17, 1-12 (2019), PubMed PMID: 31357586, PubMed PMCID: NA, DOI: 10.3390/md17080443.

  15. Wei Wang, Jianwen Cheng, Jiang-Jiang Qin, Bo Hu, Xin Li, Bhavitavya Nijampatnam, Sadanandan E Velu, Jia Fan, Xin-Rong Yang, Ruiwen Zhang, MDM2-NFAT1 Dual Inhibitor, MA242: Effective against Hepatocellular Carcinoma, Independent of p53, Cancer Letters, 459: 156-167 (2019), PubMed PMID: 31181320, PubMed PMCID: PMC6650270, DOI: 10.1016/j.canlet.2019.114429.

  16. Wei Wang, Jiang-Jiang Qin, Sukesh Voruganti, Bhavitavya Nijampatnam, Sadanandan E. Velu, Ke-He  Ruan,  Ming Hu,  Jianwei Zhou and Ruiwen Zhang, Discovery and Characterization of Dual Inhibitors of MDM2 and NFAT1 for Pancreatic Cancer Therapy, Cancer Research, 78(19): 5656-5667 (2018).  PubMed PMID:  30217928,  PMCID: PMC6435280, DOI: 10.1158/0008-5472.CAN-17-3939.

  17. Sandeep Balu Shelar, Eun-Hee Shim, Garrett J. Brinkley, Anirban Kundu, Francesca Carobbio, Tyler Poston, Jubilee Tan, Vishwas Parekh, Daniel Benson, David K. Crossman, Phillip J. Buckhaults, Dinesh Rakheja, Richard Kirkman, Yusuke Sato, Seishi Ogawa, Shilpa Dutta, Sadanandan E. Velu, Ethan Emberley, Alison Pan, Jason Chen, Tony Huang, Devin Absher, Anja Becker, Conrad Kunick, Sunil Sudarshan, Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer, Clinical Cancer Research, 24(24): 6433-6446 (2018). PubMed PMID: 30108105, PubMed PMCID: PMC6295227, DOI: 10.1158/1078-0432.CCR-18-1727.

  18. Bhavitavya NijampatnamHua Zhang,Xia Cai, Suzanne M. Michalek, Hui Wu and Sadanandan E. Velu, Inhibition of Streptococcus mutans Biofilms by the Natural Stilbene Piceatannol Through the Inhibition of Glucosyltransferases, ACS Omega, 3 (7): 8378–8385 (2018). PubMed PMID: 30087944, PubMedPMCID: PMC6072251, DOI: 10.1021/acsomega.8b00367.

  19. Shilpa Dutta, Samuel Tanner, Frédéric Gradek, Virginie Driffort, Sébastien Roger, Katri Selander and Sadanandan E. Velu (Co-corresponding author), Wayne Brouillette, Discovery and Evaluation of nNav1.5 Sodium Channel Blockers with Potent Cell Invasion Inhibitory Activity in Breast Cancer Cells, Bioorganic and Medicinal Chemistry, 26, 2428-2436 (2018). PubMed PMID: 29673714, PubMed PMCID: PMC5935567, DOI: doi.org/10.1016/j.bmc.2018.04.003.

  20. Jeffrey W. McDonald, John E. Miller, Minjee Kim and Sadanandan E. Velu, An expedient synthesis of murrayaquinone A via a novel oxidative free radical reaction, Tetrahedron Letters, 59, 550-553 (2018). PubMed PMID: 29736091, PubMed PMCID: PMC5935454, DOI: 10.1016/j.tetlet.2018.01.007.

Group

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