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Selected Publications

  1. Edwin M. Rojas, Hua Zhang, Sadanandan E. Velu, and Hui Wu, Tetracyclic homoisoflavanoid (+)-brazilin: A new inhibitor of c-di-AMP production by Streptococcus mutans, Microbiology Spectrum (2024), IN PRESS.

  2. Parmanand Ahirwar, Veronika Kozlovskaya, Bhavitavya Nijampatnam, Edwin M. Rojas, Piyasuda Pukkanasut, Daniel Inman, Maksim Dolmat, Anna C. Law, Norbert Schormann, Champion Deivanayagam, Gregory J. Harber, Suzanne M. Michalek, Hui Wu, Eugenia Kharlampieva and Sadanandan E. Velu, Hydrogel encapsulated biofilm inhibitors abrogate the cariogenic activity of Streptococcus mutans, Journal of Medicinal Chemistry (2023), 66, 7909-7925. DOI: 10.1021/acs.jmedchem.3c00272.

  3. Piyasuda Pukkanasut, Jason Whitt, Rachael Guenter, Shannon E Lynch, Carlos Gallegos, Margarita Jacaranda Rosendo-Pineda, Juan Carlos Gomora, Herbert Chen, Diana Lin, Anna Sorace, Renata Jaskula-Sztul and Sadanandan E. Velu, Voltage-gated Sodium Channel NaV1.7 Inhibitors with Potent Anticancer Activities in Medullary Thyroid Cancer Cells, Accepted for publication in Cancers (2023), 15(10), 2806, PubMed PMCID: PMC10216335, DOI: 10.3390/cancers15102806.

  4. Osbaldo Lopez-Charcas, Lucile Poisson, Oumnia Benouna, Roxane Lemoine, Stéphanie Chadet, Adrien Pétereau, Widad Lahlou, Serge Guyétant, Mehdi Ouaissi, Piyasuda Pukkanasut, Shilpa Dutta, Sadanandan E. Velu, Pierre Besson, Driffa Moussata, and Sébastien Roger, Voltage-Gated Sodium Channel NaV1.5 Controls NHE-1-Dependent Invasive Properties in Colon Cancer Cells, Cancers (2023), 15: 46, PubMed PMID: 36612049, PubMed PMCID: PMC9817685, DOI: 10.3390/cancers15010046.

  5. Cuijuan Han, Alireza Khodadadi-Jamayran, Adam H. Lorch, Qi Jin, Valentina Serafin, Ping Zhu, Yuliya Politanska, Limin Sun, Blanca T. Gutierrez-Diaz, Marina V. Pryzhkova, Hiam Abdala-Valencia, Elizabeth Thomas Bartom, Barbara Buldini, Giuseppe Basso, Sadanandan E. Velu, Kavitha Sarma, Basil B. Mattamana, Byoung-Kyu Cho, Rebecca C. Obeng, Young Ah Goo, Philip W. Jordan, Aristotelis Tsirigos, Yalu Zhou, Panagiotis Ntziachristos, SF3B1 homeostasis is critical for survival and therapeutic response in T cell leukemia, Science Advances (2022), 8, eabj8357, PubMed PMID: 35061527, PubMed PMCID: PMC8782448, DOI: 10.1126/sciadv.abj8357.

  6. Zekiye Ceren Arituluk, Jesse Horne, Bishnu Adhikari, Jeffrey Steltzner, Shomit Mansur, Parmanand Ahirwar, Sadanandan E. Velu, Nora E. Gray, Lukasz M. Ciesla and Yuping Bao,  Identification of TrkB Binders from Complex Matrices Using a Magnetic Drug Screening Nanoplatform, ACS Appl. Bio Mater. (2021), 4: 6244–6255, DOI: 10.1021/acsabm.1c00552.,  DOI: 10.1021/acsabm.1c00552.

  7. Chandni Desai, Jon Thomason, Jordan Kohlmeyer, Anna Reisetter, Parmanand Ahirwar, Khadijeh Jahanseir, Mariah Leidinger, Georgina Ofori-Amanfo, Karen Fritchie, Sadanandan E. Velu, Patrick Breheny, Dawn Quelle, and Munir Tanas, Prognostic and therapeutic value of the Hippo pathway, RABL6A, and p53-MDM2 axes in sarcomas, Submitted to Oncotarget,  12: 740-755 (2021), PubMed PMID: 33889298, PubMed PMCID: PMC8057271, DOI: 10.18632/oncotarget.27928.

  8. Bhavitavya Nijampatnam, Parmanand Ahirwar, Piyasuda Pukkanasut, Holly Womack, Luke Casals, Hua Zhang, Xia Cai, Suzanne M. Michalek, Hui Wu, and Sadanandan E. Velu, Discovery of Potent Inhibitors of Streptococcus mutans Biofilm with Antivirulence Activity, ACS Medicinal Chemistry Letters,  12 (1): 48–55 (2021), PubMed PMID: 33488963, PubMed PMCID: PMC7812604, DOI: 10.1021/acsmedchemlett.0c00373.

  9. Michiel van Gent, Adrian Reich, Sadanandan E. Velu, and Michaela U. Gack, Nonsense-mediated decay controls the reactivation of the oncogenic herpesviruses EBV and KSHV, Plos Biology, 19(2): e3001097 (2021), PubMed PMID: 33596193, DOI: 10.1371/journal.pbio.3001097.

  10. Osbaldo Lopez-Charcas, Piyasuda Pukkanasut, Sadanandan E. Velu, William J. Brackenbury, Tim G. Hales, Pierre Besson, Juan Carlos Gomora, Sebastien Roger, Pharmacological and nutritional targeting of voltage-gated sodium channels in the treatment of cancers, iScience, 24: 102270 (2021), PubMed PMID: 33817575, PubMed PMCID: PMC8010468, DOI: 10.1016/j.isci.2021.102270.

  11. Zviadi Aburjania, Jason D Whitt, Samuel Jang, Dwayaja H Nadkarni, Herbert Chen, J Bart Rose, Sadanandan E Velu (Co-corresponding author) and Renata Jaskula-Sztul, Synthetic Makaluvamine Analogs Decrease c-Kit Expression and Are Cytotoxic to Neuroendocrine Tumor Cells, Molecules, 25 (21): 4940 (2020), PubMed PMID: 33114525; PubMed PMCID: PMC7663375. DOI: 10.3390/molecules25214940.

  12. Jaden Cowan, Mohammad Shadab, Dwayaja H. Nadkarni, Kailash KC, Sadanandan E. Velu (Co-corresponding author) and Nabiha Yusuf, A Novel Marine Natural Product Derived Pyrroloiminoquinone with Potent Activity against Skin Cancer Cells, Marine Drugs, 17, 1-12 (2019), PubMed PMID: 31357586, PubMed PMCID: NA, DOI: 10.3390/md17080443.

  13. Wei Wang, Jianwen Cheng, Jiang-Jiang Qin, Bo Hu, Xin Li, Bhavitavya Nijampatnam, Sadanandan E Velu, Jia Fan, Xin-Rong Yang, Ruiwen Zhang, MDM2-NFAT1 Dual Inhibitor, MA242: Effective against Hepatocellular Carcinoma, Independent of p53, Cancer Letters (2019), 459: 156-167, PubMed PMID: 31181320, PubMed PMCID: PMC6650270, DOI: 10.1016/j.canlet.2019.114429.

  14. Wei Wang, Jiang-Jiang Qin, Sukesh Voruganti, Bhavitavya Nijampatnam, Sadanandan E. Velu, Ke-He  Ruan,  Ming Hu,  Jianwei Zhou and Ruiwen Zhang, Discovery and Characterization of Dual Inhibitors of MDM2 and NFAT1 for Pancreatic Cancer Therapy, Cancer Research, 78(19): 5656-5667  (2018).  PubMed PMID:  30217928,  PMCID: PMC6435280, DOI: 10.1158/0008-5472.CAN-17-3939.

  15. Sandeep Balu Shelar, Eun-Hee Shim, Garrett J. Brinkley, Anirban Kundu, Francesca Carobbio, Tyler Poston, Jubilee Tan, Vishwas Parekh, Daniel Benson, David K. Crossman, Phillip J. Buckhaults, Dinesh Rakheja, Richard Kirkman, Yusuke Sato, Seishi Ogawa, Shilpa Dutta, Sadanandan E. Velu, Ethan Emberley, Alison Pan, Jason Chen, Tony Huang, Devin Absher, Anja Becker, Conrad Kunick, Sunil Sudarshan, Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer, Clinical Cancer Research, 24(24): 6433-6446 (2018). PubMed PMID: 30108105, PubMed PMCID: PMC6295227, DOI: 10.1158/1078-0432.CCR-18-1727.

  16. Bhavitavya Nijampatnam, Hua Zhang,Xia Cai, Suzanne M. Michalek, Hui Wu and Sadanandan E. Velu, Inhibition of Streptococcus mutans Biofilms by the Natural Stilbene Piceatannol Through the Inhibition of Glucosyltransferases, ACS Omega 3 (7), pp 8378–8385 (2018). PubMed PMID: 30087944, PubMedPMCID: PMC6072251, DOI: 10.1021/acsomega.8b00367.

  17. Shilpa Dutta, Samuel Tanner, Frédéric Gradek, Virginie Driffort, Sébastien Roger, Katri Selander and Sadanandan E. Velu (Co-corresponding author), Wayne Brouillette, Discovery and Evaluation of nNav1.5 Sodium Channel Blockers with Potent Cell Invasion Inhibitory Activity in Breast Cancer Cells, Bioorganic and Medicinal Chemistry, 26, 2428-2436 (2018). PubMed PMID: 29673714, PubMed PMCID: PMC5935567, DOI: doi.org/10.1016/j.bmc.2018.04.003.

  18. Jeffrey W. McDonald, John E. Miller, Minjee Kim and Sadanandan E. Velu, An expedient synthesis of murrayaquinone A via a novel oxidative free radical reaction, Tetrahedron Letters, 59, 550-553 (2018). PubMed PMID: 29736091, PubMed PMCID: PMC5935454, DOI: 10.1016/j.tetlet.2018.01.007.

  19. Qiong Zhang, Bhavitavya Nijampatnam, Zhang Hua, Thao Nguyen, Jing Zou, Xia Cai, Suzanne M. Michalek, Sadanandan E. Velu (Co-corresponding author) and Hui Wu, Structure-Based Discovery of Small Molecule Inhibitors of Cariogenic Virulence, Scientific Reports,  7,  1-10  (2017). PubMed PMID: 28729722, PubMed PMCID: PMC5519559, DOI: 10.1038/s41598-017-06168-1.

  20. Bing Xue, Wei Wang, Jiang-Jiang Qin, Bhavitavya Nijampatnam, Srinivasan Murugesan, Veronika Kozlovskaya, Ruiwen Zhang, Sadanandan E. Velu (Co-corresponding author) and EugeniaKharlampieva, Highly efficient delivery of potent anticancer iminoquinone derivative by multilayer hydrogel cubes, Acta Biomaterialia, 58, 386-398 (2017). PubMed PMID: 28583901, PubMed PMCID: PMC5736006, DOI: 10.1016/j.actbio.2017.06.004.

  21. Jouko Sandholm, Jaakko Lehtimäki, Tamiko Ishizu, Sadanandan E. Velu, Jeremy Clark, Pirkko Härkönen, Arja Jukkola-Vuorinen, Aleksi Schrey, Kevin W. Harris, Johanna M. Tuomela and Katri S. Selander, Toll-like receptor 9 expression is associated with breast cancer sensitivity to the growth inhibitory effects of bisphosphonates in vitro and in vivo, Oncotarget, 7, 87373-87389 (2016). PubMed PMID: 27888633, PubMed PMCID: PMC5349995, DOI: 10.18632/oncotarget.13570.

  22. Bhavitavya Nijampatnam, Luke Casals, Ruowen Zheng, Hui Wu and Sadanandan E. Velu, Hydroxychalcone inhibitors of Streptococcus mutans glucosyl transferases and biofilms as potential anticaries agents, Bioorganic & Medicinal Chemistry Letters, 26, 3508-13 (2016). PubMed PMID: 27371109, PubMed PMCID: PMC5207028, DOI: 10.1016/j.bmcl.2016.06.033.

  23. M. Ryan Smith, Praveen K. Vayalil, Fen Zhou, Gloria A. Benavides, Reena R. Beggs, Hafez Golzarian, Bhavitavya Nijampatnam, Patsy G. Oliver, Robin A.J. Smith, Michael P. Murphy, Sadanandan E. Velu and Aimee Landar, Mitochondrial thiol modification by a targeted electrophile inhibits metabolism in breast adenocarcinoma cells by inhibiting enzyme activity and protein levels, Redox Biology, 8, 136-48 (2016). PubMed PMID: 26774751, PubMed PMCID: PMC4732023, DOI: 10.1016/j.redox.2016.01.002.

  24. Su Xu, Bhavitavya Nijampatnam, Shilpa Dutta and Sadanandan E. Velu, Cyanobacterial Metabolite Calothrixins: Recent Advances in the Synthesis and Biological Evaluation, Marine Drugs, 14, 1-21 (2016). PubMed PMID: 26771620, PubMed PMCID: PMC4728514, DOI: 10.3390/md14010017.

  25. Wei Wang, Bhavitavya Nijampatnam, Sadanandan E. Velu and Ruiwen Zhang, Discovery and Development of Synthetic Tricyclic Pyrroloquinone Alkaloid Analogs for Human Cancer Therapy, Frontiers of Chemical Science and Engineering, 10, 1-15 (2016). PubMed PMID: NA, PubMed PMCID: NA, DOI: 10.1007/s11705-016-1562-6.

  26. Annette Ehrhardt, W. Joon Chung, Louise C. Pyle, Wei Wang, Kryzysztof Nowotarski, Cory M. Mulvihill, Mohabir Ramjeesingh, Jeong Hong, Sadanandan E. Velu, Hal A. Lewis, Shane Atwell, Steve Aller, Christine E. Bear, Gergely L. Lukacs, Kevin L. Kirk, and Eric J. Sorscher, Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop, Journal of Biological Chemistry, 291, 1854-65 (2016). PubMed PMID: 26627831, PubMed PMCID: PMC4722463, DOI: 10.1074/jbc.M115.704809.

  27. Tripti Singh, Nirzari A. Gupta, Su Xu, Ram Prasad, Sadanandan E. Velu and Santosh K. Katiyar, Honokiol inhibits the growth of head and neck squamous cell carcinoma by targeting and firm binding with epidermal growth factor receptor, Oncotarget, 6, 21268-21282 (2015). PubMed PMID: 26020804, PubMed PMCID: PMC4673264, DOI: 10.18632/oncotarget.4178.

  28. Bhavitavya Nijampatnam, Shilpa Dutta and Sadanandan E. Velu, Recent developments in the isolation, synthesis, and bioactivities of bispyrroloquinone alkaloids of marine origin, Chinese Journal of Natural Medicines, 13, 561-577 (2015). PubMed PMID: NA, PubMed PMCID: PMC4710477, DOI: 10.1016/S1875-5364(15)30052-2.

  29. Qiong Zhang, Thao Nguyen, Megan McMichael, Sadanandan E. Velu, Jing Zou, Xuedong Zhou and Hui Wu, New Small Molecule Inhibitors of Dihydrofolate Reductase inhibit Streptococcus mutans, International Journal of Antimicrobial Agents, 46, 174-182 (2015). PubMed PMID: 26022931, PubMed PMCID: PMC4509821, DOI: 10.1016/j.ijantimicag.2015.03.015. 

  30. 54. Praveen K. Vayalil, Joo-Yeun Oh, Fen Zhou, Anne R. Diers, M. Ryan Smith, Hafez Golzarian, Patsy G. Oliver, Robin A. J. Smith, Michael P. Murphy, Sadanandan E. Velu and Aimee Landar,  A Novel Class of Mitochondria-Targeted Soft Electrophiles Modifies Mitochondrial Proteins and Inhibits Mitochondrial Metabolism in Breast Cancer Cells through Redox Mechanisms, PLOS ONE, 10 (3):e0120460 (2015). PubMed PMID: 25785718, PubMed PMCID: PMC4364723, DOI: 10.1371/journal.pone.0120460. 

  31. 53. Jun-Xian Yu, Sukesh Voruganti, Dan-Dan Li, Jiang-Jiang Qin, Subhasree Nag, Su Xu, Sadanandan E. Velu, Wei Wang and Ruiwen Zhang, Development and validation of an HPLC-MS/MS analytical method for quantitative analysis of TCBA-TPQ, a novel anticancer makaluvamine analog, and application in a pharmacokinetic study in rats, Chinese Journal of Natural Medicines, 13, 554-560 (2015). PubMed PMID: 26233847, PubMed PMCID: PMC4716806, DOI: 10.1016/S1875-5364(15)30051-0.

  32. Eun-Hee Shim, Carolina B. Livi, Dinesh Rakheja, Jubilee Tan, Daniel Benson, Vishwas Parekh, Eun-Young Kho, Arindam P Ghosh, Richard Kirkman, Sadanandan E. Velu, Shilpa Dutta, Balachandra Chenna, Shane L. Rea, Robert J. Mishur, Qiuhua Li, Teresa L Johnson-Pais, Lining Guo, Sejong Bae, Shi Wei, Karen Block and Sunil Sudarshan, L-2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer, Cancer Discovery, 11, 1290-1298 (2014). PubMed PMID: 25182153, PubMed PMCID: PMC4286872, DOI: 10.1158/2159-8290.CD-13-0696.

  33. Bhavitavya Nijampatnam, Dwayaja H. Nadkarni, Hui Wu and Sadanandan E. Velu, Antibacterial and Antibiofilm Activities of Makaluvamine Analogs, Microorganisms, 2, 128-139 (2014). PubMed PMID: 25767719, PubMed PMCID: PMC4354892, DOI: 10.3390/microorganisms2030128.

  34. Su Xu, Thao Nguyen, Irene Pomilio, Maria C. Vitale and Sadanandan E. Velu, Total Synthesis of Calothrixins A and B via Oxidative Radical Reaction of Cyclohexenone with Aminophenanthridinedione, Tetrahedron, 70, 5928-5933 (2014). PubMed PMID: 25663720, PubMed PMCID: PMC4313744, DOI: 10.1016/j.tet.2014.06.021.

  35. Dwayaja H. Nadkarni, Srinivasan Murugesan and Sadanandan E. Velu, Total synthesis of zyzzyanones A-D, Tetrahedron, 69, 4105-4113 (2013). PubMed PMID: 23956468, PubMed PMCID: PMC3743451, DOI: 10.1016/j.tet.2013.03.052.

  36. Kim M. Keeling, Dan Wang, Yanying Dai, Srinivasan Murugesan, Balachandra Chenna, Jeremy Clark, Valery Belakhov, Jeyakumar Kandasamy, Sadanandan E. Velu, Timor Baasov and David M. Bedwell, Attenuation of Nonsense-Mediated mRNA Decay Enhances In Vivo Nonsense Suppression, PLOS ONE, 8, e60478 (2013). PubMed PMID: 23593225, PubMed PMCID: PMC3622682, DOI: 10.1371/journal.pone.0060478.

  37. John S. Jarboe, Shilpa Dutta, Sadanandan E. Velu and Christopher D. Willey, Mini-Review:  Bmx Kinase Inhibitors for Cancer Therapy; Recent Patents on Anti-Cancer Drug Discovery, 8, 228-238 (2013). PubMed PMID: NA, PubMed PMCID: NA, DOI: NA.

  38. Deng Chen,Wei Wang, Ming-Hai Wang, Hui Wang, Srinivasan Murugesan, Dwayaja H. Nadkarni, Sadanandan E. Velu and Ruiwen Zhang; The ZAK-MKK4-JNK-TGFβ Signaling Pathway Is a Molecular Target for Novel   Synthetic Iminoquinone Analog BA-TPQ in Breast Cancer Cells; Current Cancer Drug Targets, 13, 651-660 (2013). PubMed PMID: 23607596. PubMed PMCID: NA, DOI: NA.

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